|
Title |
Titanium Oxynitride Coatings for
the Improvement of Biocompatibility and Long-Term Functionality of
Cardiovascular Stents: Development of Novel Deposition Technology |
|
Call for project |
|
|
Acronym |
TIOXTECH-BIO |
|
Contract
No. |
8
/ 2015 |
|
Romanian Coordinator |
Universitatea POLITEHNICA Bucureşti;
Facultatea de Chimie Aplicata si Stiinta
Materialelor, Str. Gh.
Polizu 1-5, Sector 1, Bucuresti,
Contact: Anton FICAI: Tel: +4021
402.3852; anton.ficai@upb.ro |
|
Contracting Authority |
|
|
Project Budget |
818 999.5
RON |
|
Period of
implementation |
04.04.2016 – 03.10.2018 |
Abstract:
Heart disease is the leading cause of death worldwide. Stenting of
arteries is a common treatment for blocked arteries and has reduced the risk of
complications and restenosis. However, restenosis is still a clinical problem
and stents are coated to prevent this. One of the most perspective stent
coating types is titanium-oxide-nitride (Ti-O-N)
deposited by magnetron sputtering. The biocompatibility improves the thicker
the coating film becomes. By increasing the film thickness, its adhesion to the
substrate deteriorates drastically causing coating defects, worsening the
stents' hemocompatibility and complicating their clinical use. TIOXTECH-BIO
will develop a new technology and improve the manufacturing of thin Ti-O-N coatings for cardiovascular stents. This will lead
to a drastic improvement of the coating quality and result in a reduced
complication risk in cardiovascular surgery.
The new technique will allow the deposition of Ti-O-N
coatings with low thickness, high hardness, low friction constant, high
corrosion, wear and oxidation resistance. In comparison to the existing
analogues (TITANOX stent, Titan-2®, Hexacath, Paris,
France) the new stent design will provide a significantly higher coating
coverage rate of the inner surface leading to a drastic decrease in the risk of
restenosis and clots building. Moreover, the new stents will be 30-70% more
cost-efficient. Vacuum ion-plasmous technologies Ltd.
will develop optimized magnetron sputtering system controlling deposition rates
optically. A low energy e-beam treatment will decrease the initial roughness of
the stent by 1-2 orders. The pioneer measurement of charge and surface
potential integrated into industrial environment will contribute to achievement
of optimal stents properties. Balton Ltd. will
introduce the results into manufacturing scale. UPB and IKTS-MD will
characterise stent coatings, compare their characteristics and evaluate new
technological possibilities.
Results:
The project results are subject to confidentiality. The results will be
patented and exploited from the point of view of their economic potential. At this
moment, two papers are already submitted and another one is ready for publish
after the approval of the partners of the consortium.
1. Nataliia Beshchasna, Au Yeung Kwan HO, Muhammad Saqib, Honorata Kraśkiewicz,
Łukasz Wasyluk, Oleg Kuzmin,
Oana Duta, Denisa Ficai, Roxana Trusca,
Anton Ficai, Vladimir F. Pichugin, Jörg
Opitz, Ecaterina Andronescu; Surface evaluation of titanium
oxynitride coatings used for developing layered cardiovascular stents,
Materials Science Engineering C, under review - revised document, submitted on
11 December 2017;
2.
Muhammad
Saqib, Muaz S. Draz,
Honorata Kraśkiewicz,
Łukasz Wasyluk, Oleg Kuzmin, Oana
Duta, Denisa Ficai, Roxana Trusca, Anton Ficai,
Vladimir F. Pichugin, Ecaterina Andronescu, Jörg Opitz, Gianaurelio Cuniberti, Nataliia Beshchasna; 
Effect of Titanium Oxynitride (TiOxNy)
coatings on corrosion behavior of stainless steel
stents; Physica Solidi-Status A – under review
3. Nataliia Beshchasna, Muhammad Saqib,
Honorata Kraśkiewicz; Łukasz Wasyluk, Oleg Kuzmin, Oana Cristina Duta,
Denisa Ficai, Zeno Ghizdăveţ, Anton Ficai, Zhilei Sun, Vladimir F. Pichugin,
Jörg Opitz, Ecaterina Andronescu; Recent advances in
manufacturing innovative stents; - will be submitted after the approval of the
partners
Prizes and Awards:
“Gold medal” – for the project “Titanium Oxynitride Coatings for the Improvement of Biocompatibility
and Long-Term Functionality of Cardiovascular Stents: Development of Novel
Deposition Technology- TIOXTECH-BIO” 22th
International Exhibition of Inventics - Inventica; 27-29. 06. 2018, Iasi, Romania
“Excelence diploma and Gold Medal” awarded by ICECHIM for the project “Titanium Oxynitride
Coatings for the Improvement of Biocompatibility and Long-Term Functionality of
Cardiovascular Stents: Development of Novel Deposition Technology-
TIOXTECH-BIO”
“Special
Prize + Gold Medal” awarded
by State University of Medicine and Pharmacy “Nicolae Testemiţanu”,
Moldova for the project “Titanium
Oxynitride Coatings for the Improvement of Biocompatibility and Long-Term
Functionality of Cardiovascular Stents: Development of Novel Deposition
Technology- TIOXTECH-BIO”
“Innovation
Award” awarded by
“Carol Davila” University of Medicine and Pharmacy, Bucharest (for the project “Titanium Oxynitride
Coatings for the Improvement of Biocompatibility and Long-Term Functionality of
Cardiovascular Stents: Development of Novel Deposition Technology-
TIOXTECH-BIO”
Best paper awarded by ASET during 8TH
International
Conference on Nanotechnology: Fundamentals
and Applications -
ICNFA'17 held at Rome, Italy for the paper Design
of TiOxNy for coating
technology, Anton Ficai, Denisa Ficai, Bogdan Stefan Vasile, Roxana
Doina Trusca, Dragos
Gudovan, Ovidiu Oprea, Motelica Ludmila, Ecaterina
Andronescu.